Advances in our understanding of quantum systems have been driven by investigations of the geometry, topology, and dimensionality of cryogenic atomic systems. NASA’s Cold Atom Laboratory (CAL) on board the International Space Station has enabled the study of ultracold atomic bubbles, a topology inaccessible on Earth. A proof-of-principle bubble experiment was performed on the CAL using the RF dressing technique. An alternative technique (double-species interaction-driven bubble) has also been proposed. Both techniques could advance discoveries in his next decade of fundamental physics research in microgravity.